Quantity: 50 tests
Controls: Colon Adenocarcinoma
Isotypes: IgG
Clone Name: SP21
Species: Rabbit
Localization: Cytoplasmic
Regulatory Status: IVD

 

 

Cyclooxygenase-2 catalyzes the conversion of arachidonic acid to prostaglandin H2 in the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. COX-2 inhibition by nonsteroidal antiinflamatory agents has been shown to decrease angiogenesis, and tumor growth, and promote apoptosis. COX-2 overexpression has been associated with increased microvascular density, and VEGF protein expression in head and neck squamous cell carcinoma and is a poor prognostic indicator in this entity as well. COX-2 overexpression has also been suggested as a poor prognostic indicator in carcinomas of the colon, breast, pancreas, and adenocarcinoma of the lung.