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TTF-1 is a 38 kD nuclear protein member of the family of homeodomain transcription factors. Exclusive expression in epithelial cells of the thyroid gland and lung allows TTF-1 to be a useful antibody for the classification of tumors arising in these organs. In context with other data, TTF-1 becomes useful in the investigation of metastatic adenocarcinomas of an unknown origin. Antibody to TTF-1 demonstrates an intranuclear staining pattern, and normal thyroid gland follicle cells and lung parenchymal alveolar lining cells serve as excellent tissue internal controls.
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